The longevity gene INDY (I’m Not Dead Yet) in metabolic control

The longevity gene INDY (I’m Not Dead Yet) in metabolic control

زمان انتشار : ۱۳۹۷/۰۱/۰۷ - ۱۲:۱۹

The regulation of metabolic processes by the Indy (I′m Not Dead Yet) (SLC13A5/NaCT) gene was revealed through studies in Drosophila melanogaster and Caenorhabditis elegans. Reducing the expression of Indy in these species extended their life span by a mechanism resembling caloric restriction, without reducing food intake. In D. melanogaster, mutating the Indy gene reduced body fat content, insulin-like proteins and reactive oxygen species production. Subsequent studies indicated that Indy encodes a #citrate #transporter located on the #cell #plasma #membrane. The transporter is highly expressed in the mammalian liver. We generated a mammalian knock out model deleting the mammalian #homolog #mIndy (#SLC13A5). The knock out animals were protected from HFD induced obesity, fatty liver and #insulin resistance. Moreover, we have shown that inducible and liver selective knock down of mIndy protects against the development of fatty liver and insulin resistance and that obese humans with type 2 #diabetes and #non-alcoholic fatty liver disease have increased levels of mIndy. Therefore, the transporter mINDY (#NaCT) has been proposed to be an ‘ideal target for the treatment of #metabolic #disease’. A small molecule inhibitor of the mINDY transporter has been generated, normalizing #glucose levels and reducing fatty liver in a model of diet induced obese mice. Taken together, studies from lower organisms, mammals and humans suggest that mINDY (NaCT) is an attractive target for the treatment of metabolic disease.

https://doi.org/10.1016/j.pharmthera.2017.10.003

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